Wednesday, February 13, 2013

Exon Skipping - Additional Reading

If you're anything like me, you get all hot and bothered about eukaryotic initiation factors and you're just dying to read more about exon skipping. The rest of you need to get with the program. Here are some links for anyone interested in diving deeper into exon skipping.

(Links after the jump)

Brief Synopses of Exon Skipping

PPMD Exon Skipping Summary

MDA Exon Skipping Summary


Prosensa Exon Skipping Summary

Leiden University Research Portal

Leiden University

Recent PlosONE Articles

This is actually about exon exchange, which would be the next step after exon skipping becomes an accepted therapy

Variants Affecting Exon Skipping Contribute to Complex Traits

Targeted Skipping of Human Dystrophin Exons in Transgenic Mouse Model Systemically for Antisense Drug Development

Identification of Small Molecule and Genetic Modulators of AON-Induced Dystrophin Exon Skipping by High-Throughput Screening

Recent News and Developments

Exon skipping to restore gene expression is promising therapeutic strategy for muscular dystrophy

This is probably one of the more important items to air recently: Dantrolene Improves Exon Skipping in Duchenne Muscular Dystrophy Models, Raising Hopes for Combination Therapy

Clinical Trial to Create an Exon Skipping Tissue Bank

Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy

No comments:

Post a Comment